Published on May 10, 2025 | 10:10 AM
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GLP-1 receptor agonists have quickly become some of the most talked-about medications for both weight loss and Type 2 diabetes. These injectable drugs mimic a natural hormone that helps regulate blood sugar, curb appetite, and support weight management. With names like Ozempic, Wegovy, and Mounjaro in the headlines, many people are asking the same question: How much is a GLP-1 without insurance?
GLP-1 (glucagon-like peptide-1) injections are a class of medications that help the body lower blood sugar and promote a feeling of fullness after eating. While originally developed for diabetes, several have been FDA-approved for weight loss as well. Some also include additional mechanisms—for example, Mounjaro and Zepbound combine GLP-1 with GIP (glucose-dependent insulinotropic polypeptide) for added effect.
Here are some of the most commonly prescribed GLP-1 and dual agonist injections:
Costs for GLP-1 injections can vary widely depending on the medication, dosage, and whether you have insurance. Below are average monthly GLP-1 prices for popular options when paying out of pocket.
Ozempic typically costs around $1,000 without insurance. It’s dosed weekly and used primarily for managing Type 2 diabetes, although it’s often prescribed off-label for weight loss.¹
Wegovy costs around $1,300 per package out-of-pocket. It contains the same active ingredient as Ozempic (semaglutide) but is FDA-approved for chronic weight management.²
Saxenda runs about $1,300 per month and is taken as a daily injection. It uses liraglutide, another GLP-1 receptor agonist, to promote weight loss and appetite control.³
Mounjaro, a dual GIP/GLP-1 receptor agonist, ranges from $1,000 per refill when not covered by insurance. It’s primarily used for diabetes but has gained popularity for weight loss as well.⁴
Zepbound, which uses the same active ingredient as Mounjaro but is approved for weight loss, costs about $1,000 per fill without insurance.⁵
The cost of compounded semaglutide can vary based on the pharmacy and formulation. It's often considered a more affordable option, but prices depend on the provider and dosage prescribed.
The cost of GLP-1 medications isn’t just about the price tag on the box—it’s influenced by several important factors that can significantly impact how much you actually pay.
One of the biggest GLP-1 price factors is whether or not your insurance plan covers the medication. Some plans might cover GLP-1s like Ozempic and Mounjaro when prescribed for Type 2 diabetes but may deny coverage for weight loss purposes. Even if a medication is covered, prior authorization and step therapy requirements can create delays or limitations.
Whether a GLP-1 is prescribed for diabetes or weight management can affect your access and cost. Many insurers are more likely to cover the medication when it’s used for diabetes, which can leave patients paying full GLP-1 price for weight loss use.
GLP-1 injections come in different strengths and dosing schedules, which can influence how much you need and how often you refill—both of which affect monthly cost.
Getting a prescription typically requires a doctor’s visit. If you don’t have insurance, these appointments, lab tests, and follow-ups can add to your overall expenses.
Where you fill your prescription also matters. Retail pharmacies, mail-order services, and compounding pharmacies may offer different pricing, and costs can vary regionally.
We know that GLP-1 medications like semaglutide and tirzepatide can be expensive—especially for those without insurance or with limited coverage. That’s why Call-On-Doc offers multiple affordable solutions to help you access the treatment you need. Here are the top ways to save on your GLP-1 prescription:
At Call-On-Doc, we believe cost shouldn’t stand in the way of your health goals. Whether you're managing Type 2 diabetes or pursuing sustainable weight loss, we offer convenient online weight loss and diabetes prescriptions with flexible, affordable options to fit your needs.
From free visits for eligible patients to discounted compounded semaglutide, savings cards, and pharmacy tools, we’re here to help make GLP-1 treatment accessible—no insurance required.
Sources:
English graduate and Call-On-Doc’s medical resource guide, Wayne C. Hahne is an experienced and passionate medical education content expert. Through diligent research, provider interviews and utilizing the industry's leading resources for wellness information, it is Mr. Hahne’s personal mission to educate the general public on medical conditions with in-depth and easy-to-understand written guides.
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