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The Call-On-Doc Guide to Acne

Published on Jun 02, 2023 | 4:10 PM

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Acne is often portrayed as a teenage problem, but it can affect people of all ages—from adolescents to adults in their 30s, 40s, and beyond. In the United States, acne affects tens of millions of people each year, and adult acne is increasingly common, especially in women. The good news is that acne is treatable, and today’s care standards focus on matching treatment to acne type, severity, and skin sensitivity to prevent scarring and improve long-term control.

What does acne look like?

There is no single universal grading scale used everywhere, but clinicians evaluate acne using the same core factors: the type and number of lesions, the degree of inflammation, where breakouts occur, and whether scarring is present. “Acne lesions” (pimples) are the most recognizable sign, but redness, tenderness, and post-inflammatory discoloration can also be part of acne. Picking, popping, or aggressively scrubbing can worsen inflammation, prolong healing, and increase the risk of scarring.

Common lesion types include:

  • Blackheads (open comedones)
  • Whiteheads (closed comedome)
  • Papules (smallinflamed bumps)
  • Pustules (inflamed bumps with pus)
  • Nodules and cyst (deeper, painfullesions that can scar)
what-does-acne-look-like

What are the different types of acne?

Acne can show up in different patterns, and identifying the type helps guide the most effective treatment plan.
Cystic acne: A severe form of acne with deep, painful, inflamed cysts that form under the skin and can lead to scarring.
Nodular acne: Large, firm, tender nodules under the skin that are more resistant to over-the-counter treatments and often require prescription therapy.
Hormonal acne: Often seen in adults and linked to hormone shifts. Breakouts commonly cluster on the lower face, jawline, and chin, and may worsen around menstrual cycles or with hormonal transitions.
Fungal acne (Malassezia folliculitis): Not true acne vulgaris, but it can look similar. It tends to cause small, uniform, itchy bumps—often on the chest, back, shoulders, or forehead—and may worsen with heat, sweat, and occlusive products. It typically responds to antifungal treatment rather than standard acne antibiotics.
 

Is acne caused by other medical conditions?

Acne is not usually a symptom of a single disease, but it can be influenced by hormones, genetics, medications, and certain health conditions. In some cases, disorders such as PCOS, Cushing syndrome, or adrenal disorders can contribute to persistent or severe acne. Certain medications—especially corticosteroids and some anticonvulsants—can also trigger acne-like eruptions.

Is acne face mapping accurate?

Acne face mapping—the idea that breakouts in specific facial zones reliably indicate internal organ problems—is not supported by strong scientific evidence. Acne distribution can reflect oil gland density, product use, friction (masks/helmets), hormones, and individual skin behavior more than internal “mapping.”

What causes acne?

Acne forms when pores (hair follicles) become clogged with a combination of oil (sebum), dead skin cells, and debris. This creates an environment where inflammation can develop and bacteria can contribute to breakouts. Core drivers include:

  • Excess oil production
  • Clogged pores from abnormal skin shedding
  • Inflammation
  • Bacterial contribution (Cutibacterium acnes) in some acne types)

What causes acne to get worse?

Several factors can worsen acne or make it harder to control:

  • Hormonal shifts (puberty, cycles, pregnancy, menopause, starting/stopping birth control)
  • Stress and poor sleep
  • Friction and occlusion (masks, helmets, tight clothing)
  • Harsh skincare, overwashing, or frequent picking
  • Certain medications (notably steroids; others vary by person)
  • Diet patterns that may increase inflammation for some people (often high-glycemic foods; dairy may worsen acne in some individuals)
     
what-causes-acne-to-get-worse

How is acne diagnosed?

Acne is usually diagnosed with a visual skin exam. A clinician evaluates lesion type, severity, distribution (face, chest, back), and signs of scarring or post-inflammatory discoloration. Your medical history, current medications, menstrual patterns (when relevant), and skincare routine can help identify triggers and guide treatment selection.

Which treatment is best for acne?

The best treatment depends on acne type and severity. Current standards emphasize combination therapy when appropriate, consistent use for several weeks, and preventing antibiotic resistance by avoiding antibiotic-only regimens.
Topical treatments (first-line for most mild to moderate acne)

Topicals work directly in the pores and on the skin surface. Common evidence-based options include:

  • Benzoyl peroxide: reduces acne-causing bacteria and inflammation; helps prevent antibiotic resistance when used with topical or oral antibiotics.
  • Topical retinoids (adapalene, tretinoin): normalize skin cell turnover, prevent clogged pores, and treat comedones; cornerstone of long-term maintenance.
  • Azelaic acid: reduces inflammation and helps with post-acne dark marks; often well tolerated in sensitive skin.
  • Topical antibiotics (when indicated): used in combination with benzoyl peroxide to reduce resistance risk.
  • Clascoterone (topical antiandrogen): an option for hormonal-pattern acne in appropriate patients.
     

Oral treatments (for moderate to severe acne, widespread acne, or scarring risk)

  • Oral antibiotics (often doxycycline/minocycline/sarecycline): used for inflammatory acne for the shortest effective duration, typically about 3–4 months, and paired with topical benzoyl peroxide and a retinoid for maintenance.
  • Hormonal therapy (for eligible women): combined oral contraceptives and/or spironolactone can improve hormonally driven acne by reducing androgen effects on oil glands.
  • Isotretinoin: reserved for severe acne, scarring acne, or acne causing significant psychosocial burden, and requires close monitoring and strict pregnancy prevention safeguards.
     

In-office and procedural options (for select cases)

  • Chemical peels and microdermabrasion may help certain acne patterns and post-acne marks when done appropriately.
  • Intralesional steroid injections can rapidly reduce painful cysts or nodules.
  • Incision and drainage is used for select large lesions by trained professionals.

Tips for acne management

  • Cleanse gently twice daily; avoid harsh scrubs.
  • Use non-comedogenic skincare and makeup.
  • Do not pick or squeeze lesions to reduce scarring risk.
  • Protect your skin with broad-spectrum SPF 30+ daily, especially when using retinoids or acids.
  • Keep hair products off the face and avoid occlusive, greasy products if they trigger breakouts.
  • Give treatments time; most regimens take 6–12 weeks to show meaningful improvement.

What is the best way to apply topicals on your face?

  1. Wash your face with a gentle cleanser and lukewarm water.
  2. Pat dry—do not rub.
  3. Apply your acne medication in a thin layer as directed.
  4. Allow a few minutes for absorption.
  5. Moisturize if needed with a non-comedogenic moisturizer.

When to get help

If your acne is painful, leaving dark marks or scars, affecting large areas (like the back or chest), or not improving after consistent use of over-the-counter treatments, it’s time for a personalized plan. With CallOnDoc, you can start an online visit and receive a treatment plan designed for your acne type, skin sensitivity, and long-term goals.

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Shelly House, FNP-BC,

updated 1/20/2026 Shelly House, FNP, is a Family Nurse Practitioner and Call-On-Doc’s trusted medical education voice. With extensive experience in telehealth and patient-centered care, Ms. House is dedicated to making complex health topics simple and accessible. Through evidence-based content, provider collaboration, and a passion for empowering patients, her mission is to break down barriers to healthcare by delivering clear, compassionate, and practical medical guidance.

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