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5 Things to Check When You Get a New Prescription

Published on Dec 17, 2025 | 7:42 AM

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Whether it's for a chronic condition, an infection, or a one-time issue, getting a new prescription should feel reassuring — not confusing. But the reality is that medication errors remain a major safety issue worldwide.
Studies estimate that about 1 in every 20 patients experience medication-related harm, often from misunderstandings, incorrect dosing, drug interactions, or simple miscommunication.

The good news?
A few quick checks can dramatically reduce your risk and help you take your medication confidently and safely.

Here are the 5 most important things to check every time you start a new prescription.

1. Double-Check the Name of the Medication

Medications often have two names:

  • Brand name (e.g., Zithromax)

  • Generic name (e.g., azithromycin)

It’s common for pharmacies to substitute the generic — which is perfectly safe — but the change in name can confuse patients.

Always confirm:

  • Is this the medication my provider prescribed?

  • Is this the brand or generic version?

  • Are the pills, capsules, or packaging unfamiliar compared to what I’ve had before?

If something looks different, ask.
A 10-second question can prevent major medication errors.

2. Know the Right Dose — and Whether It’s Safe for You

Dosing mistakes are one of the most common causes of medication harm.

When you receive your prescription, check:

  • How much you should take

  • How often

  • For how many days

  • Whether the dose is safe for your age, kidney function, liver function, and weight

Examples:

  • Some antibiotics are taken once daily, others twice daily

  • Steroids like prednisone must follow specific tapers

  • Blood pressure meds differ in strength depending on other conditions

If the instructions feel unclear, don’t guess — message your provider.

3. Identify Interactions With Your Other Medications

Even safe medications can become risky when combined with others.

Always check:

  • Prescription medications

  • Over-the-counter meds (ibuprofen, antihistamines, sleep aids)

  • Supplements (magnesium, St. John’s Wort, fish oil)

  • Recreational substances (alcohol, cannabis)

Examples:

  • Ibuprofen + certain blood pressure meds can stress the kidneys

  • Antibiotics + birth control may reduce contraceptive effectiveness

  • Fluconazole + statins can affect liver metabolism

  • Decongestants + hypertension may raise blood pressure

Your pharmacy, provider, or even an app can check interactions instantly — but only if you ask.

4. Understand How and When to Take It

How you take a medication changes how well it works.

Check:

  • Should it be taken with food or on an empty stomach?

  • Morning or evening?

  • Should the pill be swallowed whole, chewed, or dissolved?

  • Are there foods or drinks to avoid (grapefruit, dairy, caffeine)?

  • Should you avoid alcohol while taking it?

  • Can you drive or work safely on this medication?

Small details matter:

  • Some antibiotics don’t absorb well with dairy

  • Thyroid medication works best on an empty stomach

  • Many medications cause drowsiness — or the opposite, insomnia

Your safety and results depend on these small but crucial instructions.

5. Know the Red Flags and When to Seek Help

Every medication has benefits — and potential side effects.

You should know:

  • Common, expected side effects

  • What’s normal vs. what’s concerning

  • Emergency symptoms that require immediate care

For example:

  • Mild nausea with antibiotics? Common.

  • Severe rash? Not normal — stop and contact a provider.

  • Drowsiness with an allergy medication? Expected.

  • Trouble breathing? Emergency.

At CallOnDoc, we always highlight what to watch for, but you can (and should) ask for clarification whenever something feels unclear.

Bonus Tip: Keep a Medication List (Your Future Self Will Thank You)

A simple list or medication-tracking app can:

  • Prevent drug interactions

  • Help providers adjust dosages

  • Make ER visits safer

  • Ensure accurate telehealth care

Include:

  • Name

  • Dose

  • Frequency

  • Reason for taking it

  • Start date

  • Who prescribed it

  • Any reactions you’ve had

This protects you — and helps us provide better care.

How CallOnDoc Helps You Stay Safe

When you receive a prescription through CallOnDoc, you also get:

  • Clear instructions written in plain language

  • Details on how to take your medication correctly

  • Side-effect warnings

  • Interaction screening

  • Follow-up if symptoms don’t improve

  • The ability to message your provider with questions

Our goal is simple: Medicine Made Easy — and safe.

Final Takeaway

A new prescription shouldn’t be stressful.
By checking these five key things —
✔ the medication name
✔ the dose
✔ interactions
✔ usage instructions
✔ red flags —
you can dramatically reduce errors and feel more confident in your care.

Taking a few minutes to double-check could prevent a medication problem later — and can be one of the most important steps you take for your health.

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Shelly House, FNP,

Shelly House, FNP, is a Family Nurse Practitioner and Call-On-Doc’s trusted medical education voice. With extensive experience in telehealth and patient-centered care, Ms. House is dedicated to making complex health topics simple and accessible. Through evidence-based content, provider collaboration, and a passion for empowering patients, her mission is to break down barriers to healthcare by delivering clear, compassionate, and practical medical guidance.

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