Published on Jun 08, 2022 | 2:56 PM
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As research on COVID-19 continues to evolve, the healthcare community closely follows updated treatment guidance and safety recommendations from the U.S. Food and Drug Administration (FDA). These guidelines help ensure that patients receive effective treatment while minimizing the risk of severe COVID-19 outcomes.
Paxlovid (nirmatrelvir/ritonavir) is an FDA-authorized antiviral medication used to treat mild to moderate COVID-19 in patients at high risk for progression to severe disease, including hospitalization or death.
To be prescribed Paxlovid, patients must meet all of the following criteria:
Have confirmed positive results for SARS-CoV-2
Be 12 years of age or older and weigh at least 88 pounds (40 kg)
Have mild to moderate COVID-19 symptoms
Have one or more risk factors for progression to severe COVID-19 (such as older age or certain underlying medical conditions)
Be able to start treatment within 5 days of symptom onset
According to FDA guidance, Paxlovid is not authorized for:
Prevention of COVID-19
Use as a substitute for COVID-19 vaccination
Treatment of patients hospitalized due to severe or critical COVID-19
Individuals who test positive for SARS-CoV-2 but do not have symptoms
Individuals without risk factors for progression to severe COVID-19
Clinical trial data submitted under FDA authorization showed that among high-risk, non-hospitalized adults treated early, Paxlovid reduced the risk of hospitalization or death by approximately 88% compared with placebo.
Ongoing studies continue to monitor effectiveness, resistance patterns, and safety across different populations. As of now, Paxlovid remains an important treatment option for eligible high-risk patients.
Patients prescribed Paxlovid should be aware of possible side effects and precautions, including:
Altered or metallic taste
Diarrhea
Increased blood pressure
Muscle aches
Additional important considerations:
Paxlovid may contribute to HIV-1 drug resistance in people with untreated or undiagnosed HIV-1 infection
It can cause significant drug–drug interactions when taken with certain medications
It is not recommended for patients with severe kidney or liver impairment
A healthcare provider will review your medical history and current medications to determine whether Paxlovid is safe for you.
If you think you may qualify for Paxlovid, a licensed provider can help evaluate your symptoms, risk factors, and medication history.
You can consult online with a Call-On-Doc provider to determine whether Paxlovid is an appropriate treatment option for you.
updated 1/2/2026
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