Published on Sep 01, 2026 | 2:34 PM
You've had that mole for years.
Then one day you look at it and think:
“Has that always looked like that?”
Maybe it's darker.
Maybe the edges seem different.
Maybe it's larger—or you're suddenly noticing a spot that wasn't there before.
Most moles are harmless. But a mole that's new, changing, unusual, or noticeably different from the rest of your moles deserves a closer look.
One of the easiest ways to remember what to watch for is the ABCDE rule:
A — Asymmetry: One half doesn't match the other.
B — Border: The edges are irregular, blurred, or poorly defined.
C — Color: The mole has multiple colors or uneven pigmentation.
D — Diameter: It's larger than about 6 millimeters, although melanomas can be smaller.
E — Evolving: It's changing in size, shape, color, elevation, or symptoms.
That last one—evolving—is especially important.
A mole doesn't have to perfectly match every ABCDE warning sign to be worth checking.
A mole, medically called a nevus, develops when pigment-producing cells called melanocytes grow in a cluster.
Moles can be flat or raised.
They may be tan, brown, black, pink, or similar to your natural skin tone.
Some are present from childhood, while others develop later.
It's normal for adults to have multiple moles, and the vast majority never become cancerous.
That's why the goal isn't to become afraid of every spot on your skin.
It's to learn what your normal looks like so you're more likely to notice when something changes.
Imagine drawing a line through the middle of the mole.
Do the two halves generally resemble each other?
Many benign moles are relatively symmetrical.
A lesion where one side looks significantly different from the other may deserve evaluation.
Look at the outer edge.
Typical moles often have relatively smooth, defined borders.
A concerning lesion may have edges that appear irregular, scalloped, notched, blurred, or difficult to define.
If the border seems to be changing, that's another reason to pay attention.
A typical mole often has fairly consistent coloring.
A lesion containing several shades—such as brown, black, red, white, or blue—or one that's developing new areas of pigmentation may need evaluation.
But color alone doesn't diagnose melanoma.
Some melanomas may have relatively uniform coloring, and some benign moles can contain more than one shade.
That's why the whole pattern matters.
You've probably heard the “pencil eraser rule.”
A diameter greater than about 6 millimeters—roughly the size of a pencil eraser—is traditionally considered one warning sign.
But don't wait for a spot to become large before having it checked.
Melanomas can be smaller than 6 millimeters.
A small lesion that's rapidly changing may be more concerning than a larger mole that's looked identical for decades.
This may be the most useful warning sign of all.
Is the mole changing?
That might mean it's:
Getting larger
Becoming darker or lighter
Changing shape
Developing new colors
Becoming raised
Beginning to itch
Bleeding
Crusting
Becoming painful or tender
A changing lesion doesn't automatically mean cancer.
But change is information your healthcare provider should know about.
There's another skin-check strategy that's surprisingly simple.
Look for the mole that doesn't belong with the others.
Most people's moles tend to follow a pattern.
Maybe yours are mostly small and light brown.
Or perhaps they're slightly raised and similar in size.
Then there's one that's larger, darker, oddly shaped, or simply looks completely different.
Dermatologists sometimes refer to this as the “ugly duckling” sign.
The important comparison isn't always your mole versus a photograph online.
Sometimes it's:
This mole versus all of your other moles.
If one spot clearly stands out, it's worth paying attention to.
An irritated mole can itch or bleed for harmless reasons.
Maybe your bra strap repeatedly rubs against it.
Maybe you caught it while shaving.
Maybe clothing scratched it.
But a mole that repeatedly bleeds, crusts, itches, becomes painful, or develops a sore that doesn't heal should be evaluated—particularly when there's no obvious injury causing the problem.
Don't repeatedly pick at or treat the spot at home.
Give your provider the opportunity to determine what it actually is.
Developing new moles during childhood and young adulthood can be normal.
New pigmented lesions appearing later in adulthood deserve a little more attention.
That doesn't mean every new spot after age 40 is melanoma.
Far from it.
Seborrheic keratoses, sun spots, skin tags, and other benign growths become increasingly common with age and can sometimes be mistaken for moles.
But a new or changing pigmented lesion in an adult is worth monitoring and, when concerning or uncertain, evaluating.
Anyone can develop skin cancer, regardless of skin tone.
However, certain factors can increase melanoma risk, including:
Significant UV or sun exposure
History of blistering sunburns
Indoor tanning
Having many moles
Having atypical moles
Personal history of melanoma or other skin cancers
Family history of melanoma
Certain genetic factors
A weakened immune system
People with darker skin tones can also develop melanoma.
In darker skin, melanoma may sometimes occur in less sun-exposed areas, including the palms, soles, or underneath the nails.
Skin cancer awareness should include every skin tone.
A skin check shouldn't stop at the areas you can easily see in the mirror.
Suspicious lesions can appear on the scalp, behind the ears, between the toes, on the soles of the feet, and around or underneath the nails.
Use mirrors when needed, and consider asking someone you trust to look at areas such as your back or scalp.
If you notice a new dark streak underneath a nail—particularly one that changes, widens, or extends into the surrounding skin—have it evaluated rather than assuming it's simply a bruise.
For some people, yes.
Taking clear photographs can make it easier to recognize changes over time, especially if you have several moles.
Try to use similar lighting and angles each time.
Including a ruler or another size reference can also make comparison easier.
But photographs aren't a substitute for professional evaluation when a lesion looks concerning.
They're a tool for answering an important question:
“Has this actually changed?”
Have a mole or skin lesion evaluated if:
It is new and unusual.
It is changing in size, shape, or color.
One half looks different from the other.
Its borders become irregular or poorly defined.
It develops several different colors.
It grows rapidly.
It looks noticeably different from your other moles.
It repeatedly itches, bleeds, crusts, or becomes painful.
A sore doesn't heal.
You notice a concerning lesion on the palm, sole, scalp, or underneath a nail.
You're simply uncertain whether a spot is normal.
You don't need to wait until a mole checks every box on the ABCDE list.
One meaningful change can be enough reason to have it evaluated.
A changing mole isn't something you want to ignore—but it also doesn't automatically mean you have skin cancer.
Through CallOnDoc's secure asynchronous online medical evaluation, you can provide information about a skin concern, including when you first noticed it, how it has changed, symptoms, medical history, and other relevant details without routinely scheduling a live video appointment.
When clinically appropriate, a licensed healthcare provider can review your concern and help determine whether a lesion may be suitable for telehealth assessment or whether you should see a dermatologist or other healthcare professional in person.
Some skin conditions can be evaluated and treated online.
A suspicious mole is different.
If a lesion may need dermoscopic examination, biopsy, or removal, an in-person dermatology evaluation is the appropriate next step.
That's an important part of telehealth too: recognizing when a photograph isn't enough.
The goal isn't to tell you every mole is harmless.
It's to help you recognize which ones shouldn't wait.
No. Many benign moles can have irregular features. However, a mole that's changing or has concerning characteristics should be evaluated.
No. Many harmless moles are larger than 6 millimeters, and melanomas can also be smaller. Size is only one part of the evaluation.
A change in elevation can be worth evaluating, especially if it occurs along with changes in size, color, shape, bleeding, itching, or other symptoms.
Sometimes melanoma can be subtle, particularly early on. That's why changes over time and the “ugly duckling” sign can be useful in addition to the ABCDE rule.
Yes. Melanoma can occur in every skin tone. In darker skin, it may sometimes develop on areas such as the palms, soles, or underneath the nails.
Photos and telehealth assessment may help determine whether a lesion needs further evaluation, but suspected melanoma typically requires an in-person skin examination and often a biopsy for diagnosis.
You don't need to panic every time you discover a new spot.
And you don't need to memorize every possible appearance of skin cancer.
Instead, learn your skin.
Know what your moles usually look like.
Remember the ABCDE rule.
And pay particular attention to anything that's evolving or looks different from everything around it.
If you find yourself repeatedly looking at the same mole and wondering:
“Has that always looked like that?”
Take that question seriously.
Most suspicious-looking spots won't turn out to be melanoma.
But when skin cancer is present, recognizing a concerning change and getting it evaluated early can make an important difference.
Shelly House,is a Family Nurse Practitioner and Call-On-Doc’s trusted medical education voice. With extensive experience in telehealth and patient-centered care, Ms. House is dedicated to making complex health topics simple and accessible. Through evidence-based content, provider collaboration, and a passion for empowering patients, her mission is to break down barriers to healthcare by delivering clear, compassionate, and practical medical guidance.
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